CENTRAL ASIAN JOURNAL OF NEPHROLOGY
Review Article
Jul 22, 2025 51 12

Toward Precision Medicine in Diabetic Kidney Disease: The Call for Integrative Genomic Research in Kazakhstan

Binura Taurbekova 1 * ,
Kymbat Mukhtarova 1,
Kuralay Atageldiyeva 2 3,
Antonio Sarria-Santamera 1
1 Department of Biomedical Sciences, School of Medicine, Nazarbayev University, Astana, Kazakhstan2 Department of Medicine, School of Medicine, Nazarbayev University, Astana, Kazakhstan3 Department of Medicine, «University Medical Center» Corporate Fund, Astana, Kazakhstan* Corresponding Author
Central Asian Journal of Nephrology, 1(1), 2025, cajn002
Publication date: Jul 22, 2025
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ABSTRACT

Diabetic kidney disease (DKD) is a major complication of diabetes mellitus and the leading cause of end-stage renal disease (ESRD) worldwide. Despite considerable research efforts, the pathogenesis of DKD remains incompletely understood, largely due to its multifactorial etiology and pronounced phenotypic heterogeneity. Genome-wide association studies (GWAS) have identified over 40 loci associated with DKD; however, these common variants collectively explain only a small fraction of the disease’s heritability. Rare and low-frequency variants, often undetected by GWAS, are increasingly recognized as important contributors, and next-generation sequencing (NGS) technologies offer valuable tools for their identification. Kazakhstan, characterized by a unique genetic landscape and substantial ethnic admixture, remains underrepresented in DKD genomics research. Expanding integrative, high-resolution genomic studies in such settings is essential for identifying population-specific risk variants, improving diagnostic accuracy, and advancing precision medicine approaches to DKD prevention and management.

KEYWORDS

Diabetic Nephropathy Diabetes Mellitus Genome-Wide Association Study Next-Generation Sequencing Single Nucleotide Polymorphism Genetic Susceptibility Loci

CITATION (Vancouver)

Taurbekova B, Mukhtarova K, Atageldiyeva K, Sarria-Santamera A. Toward Precision Medicine in Diabetic Kidney Disease: The Call for Integrative Genomic Research in Kazakhstan. Central Asian Journal of Nephrology. 2025;1(1):cajn002.
APA
Taurbekova, B., Mukhtarova, K., Atageldiyeva, K., & Sarria-Santamera, A. (2025). Toward Precision Medicine in Diabetic Kidney Disease: The Call for Integrative Genomic Research in Kazakhstan. Central Asian Journal of Nephrology, 1(1), cajn002.
Harvard
Taurbekova, B., Mukhtarova, K., Atageldiyeva, K., and Sarria-Santamera, A. (2025). Toward Precision Medicine in Diabetic Kidney Disease: The Call for Integrative Genomic Research in Kazakhstan. Central Asian Journal of Nephrology, 1(1), cajn002.
AMA
Taurbekova B, Mukhtarova K, Atageldiyeva K, Sarria-Santamera A. Toward Precision Medicine in Diabetic Kidney Disease: The Call for Integrative Genomic Research in Kazakhstan. Central Asian Journal of Nephrology. 2025;1(1), cajn002.
Chicago
Taurbekova, Binura, Kymbat Mukhtarova, Kuralay Atageldiyeva, and Antonio Sarria-Santamera. "Toward Precision Medicine in Diabetic Kidney Disease: The Call for Integrative Genomic Research in Kazakhstan". Central Asian Journal of Nephrology 2025 1 no. 1 (2025): cajn002.
MLA
Taurbekova, Binura et al. "Toward Precision Medicine in Diabetic Kidney Disease: The Call for Integrative Genomic Research in Kazakhstan". Central Asian Journal of Nephrology, vol. 1, no. 1, 2025, cajn002.

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