Keyword: Heart Failure
2 results found.
Case Report
Central Asian Journal of Nephrology, 1(2), 2025, cajn010, https://doi.org/10.63946/cajn/17568
ABSTRACT:
A 68-year-old asian man was admitted with decompensated chronic heart failure with a left ventricular ejection fraction of 20%, permanent arterial fibrillation, and chronic kidney disease. Sacubitril/Valsartan (Uperio) was prescribed. This review details the initiation of sacubitril/valsartan in an Asian patient with heart failure with low ejection fraction (20%) and comorbidities. The paper highlights the pharmacodynamic and pharmacokinetic profiles of Sacubitril/Valsartan. The focus is on a thorough review of clinical trials to assess the therapeutic efficacy and potential adverse events associated with Sacubitril/Valsartan administration in this specific patient group.
Since 2014, sacubitril/valsartan has been widely prescribed for heart failure. Nevertheless, the coexistence of additional diseases such as arthritis, renal insufficiency, diabetes mellitus, or chronic lung disease with the heart failure syndrome should logically require a modification of treatment, outcome assessment, or follow-up care.
Since 2014, sacubitril/valsartan has been widely prescribed for heart failure. Nevertheless, the coexistence of additional diseases such as arthritis, renal insufficiency, diabetes mellitus, or chronic lung disease with the heart failure syndrome should logically require a modification of treatment, outcome assessment, or follow-up care.
Original Article
Central Asian Journal of Nephrology, 1(1), 2025, cajn001, https://doi.org/10.63946/cajn/16627
ABSTRACT:
Background: Despite the fact that the prevalence of CKD and its effects on health have been studied mainly in economically developed countries, the burden of this disease is even greater in developing countries. It has been established that more than 50% of deaths in patients with ESRD are due to cardiovascular causes. The objective of our study is to comparatively study the structure of cardiovascular diseases in dialysis patients at different levels of health care in Uzbekistan.
Methods: 165 dialysis patients (90 men and 75 women) were studied. The main initial diseases were chronic glomerulonephritis (n=76), diabetes mellitus (n=44), urolithiasis (n=14), chronic pyelonephritis (n=10), etc. Patients were included from 3 clinics of different administrative levels - republican (n=32), urban (n=72) and rural (n=61).
Results: CVDs were identified in 69% of the urban, 44% of the regional and 47% of the republican population. In the structure of CVD, AH, IHD and CHF prevailed in all groups. Also, in the groups of the republican and city level, CVD was more common in a combined form, while dialysis patients at the regional level had more isolated CVD pathology.
Conclusion: Patients of the urban population on dialysis more often suffer from CVD than patients receiving HD at the republican and regional levels of health care. The combined lesion of the CVS occupies a leading place in the structure of CVD in dialysis patients at both urban and national levels.
Methods: 165 dialysis patients (90 men and 75 women) were studied. The main initial diseases were chronic glomerulonephritis (n=76), diabetes mellitus (n=44), urolithiasis (n=14), chronic pyelonephritis (n=10), etc. Patients were included from 3 clinics of different administrative levels - republican (n=32), urban (n=72) and rural (n=61).
Results: CVDs were identified in 69% of the urban, 44% of the regional and 47% of the republican population. In the structure of CVD, AH, IHD and CHF prevailed in all groups. Also, in the groups of the republican and city level, CVD was more common in a combined form, while dialysis patients at the regional level had more isolated CVD pathology.
Conclusion: Patients of the urban population on dialysis more often suffer from CVD than patients receiving HD at the republican and regional levels of health care. The combined lesion of the CVS occupies a leading place in the structure of CVD in dialysis patients at both urban and national levels.