The Central Asian Journal of Nephrology (CAJN) aims to provide a platform for the dissemination of high-quality research, clinical studies and expert opinions in the field of nephrology. It is dedicated to improving the understanding, prevention, diagnosis and treatment of kidney diseases in Central Asia and beyond. The journal aims to promote collaboration between researchers, clinicians and healthcare professionals to address the unique challenges in nephrology faced by the Central Asian region, because of its same cultural and environment factors, genetic background and similar healthcare models.

Call for Publications

The Central Asian Journal of Nephrology invites researchers from all over the world, clinicians, healthcare professionals, and policymakers to submit manuscripts that contribute to advancing knowledge and practice in nephrology, accommodating its regional focus and the specialized field of nephrology, while ensuring relevance to both local and international audiences.

We welcome original research, reviews, case reports, and methodological papers that explore all aspects of kidney health and disease. Topics of interest include, but are not limited to:

Prevention, diagnosis, and management of acute and chronic kidney diseases
Dialysis and renal transplantation
Basic science research in nephrology
Epidemiological studies on kidney disease burden
Public health and policy innovations in nephrology
Applications of data science, digital health, and AI in nephrology
Real-world evidence, patient-centered outcomes, and healthcare equity

The journal seeks to disseminate high-quality, interdisciplinary research that enhances clinical practice, informs policy, and promotes kidney health across Central Asia and beyond.

We encourage submissions that reflect regional insights, cross-national collaborations, and innovative approaches to addressing the growing challenges of kidney diseases.

Submit your manuscript today and join us in shaping the future of nephrology in Central Asia and beyond.

CURRENT ISSUE

Volume 1, Issue 1, 2025

(Ongoing)

Original Article

Cardiovascular Diseases in Dialysis Patients at Different Levels of Healthcare of the Republic of Uzbekistan

Olimkhon Sharapov, Botir Daminov

Central Asian Journal of Nephrology, 1(1), 2025, cajn001

ABSTRACT: Background: Despite the fact that the prevalence of CKD and its effects on health have been studied mainly in economically developed countries, the burden of this disease is even greater in developing countries. It has been established that more than 50% of deaths in patients with ESRD are due to cardiovascular causes. The objective of our study is to comparatively study the structure of cardiovascular diseases in dialysis patients at different levels of health care in Uzbekistan.
Methods: 165 dialysis patients (90 men and 75 women) were studied. The main initial diseases were chronic glomerulonephritis (n=76), diabetes mellitus (n=44), urolithiasis (n=14), chronic pyelonephritis (n=10), etc. Patients were included from 3 clinics of different administrative levels - republican (n=32), urban (n=72) and rural (n=61).
Results: CVDs were identified in 69% of the urban, 44% of the regional and 47% of the republican population. In the structure of CVD, AH, IHD and CHF prevailed in all groups. Also, in the groups of the republican and city level, CVD was more common in a combined form, while dialysis patients at the regional level had more isolated CVD pathology.
Conclusion: Patients of the urban population on dialysis more often suffer from CVD than patients receiving HD at the republican and regional levels of health care. The combined lesion of the CVS occupies a leading place in the structure of CVD in dialysis patients at both urban and national levels.

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Jul 21, 2025

Review Article

Toward Precision Medicine in Diabetic Kidney Disease: The Call for Integrative Genomic Research in Kazakhstan

Binura Taurbekova, Kymbat Mukhtarova, Kuralay Atageldiyeva, Antonio Sarria-Santamera

Central Asian Journal of Nephrology, 1(1), 2025, cajn002

ABSTRACT: Diabetic kidney disease (DKD) is a major complication of diabetes mellitus and the leading cause of end-stage renal disease (ESRD) worldwide. Despite considerable research efforts, the pathogenesis of DKD remains incompletely understood, largely due to its multifactorial etiology and pronounced phenotypic heterogeneity. Genome-wide association studies (GWAS) have identified over 40 loci associated with DKD; however, these common variants collectively explain only a small fraction of the disease’s heritability. Rare and low-frequency variants, often undetected by GWAS, are increasingly recognized as important contributors, and next-generation sequencing (NGS) technologies offer valuable tools for their identification. Kazakhstan, characterized by a unique genetic landscape and substantial ethnic admixture, remains underrepresented in DKD genomics research. Expanding integrative, high-resolution genomic studies in such settings is essential for identifying population-specific risk variants, improving diagnostic accuracy, and advancing precision medicine approaches to DKD prevention and management.