CENTRAL ASIAN JOURNAL OF NEPHROLOGY
Original Article
Mar 30, 2026 5 5

A Study of Glomerular Filtration and Kidney Volume in Patients with Alcohol Dependence

Erdenebat Nayanbuu 1 * ,
Ganbat Dorjpalam 1,
Zoljargal Sainjargal 1,
Nyamsuren Altan 1,
Khorolgarav Aviisuren 2
1 Department of Treatment, Addiction center of Ulaanbaatar, Ulaanbaatar, Mongolia2 Department of Central Clinical Laboratory, First Central Hospital of Mongolia, Ulaanbaatar, Mongolia* Corresponding Author
Central Asian Journal of Nephrology, 2(1), 2026, cajn011, https://doi.org/10.63946/cajn/18271
Publication date: Mar 30, 2026
Full Text (PDF)

ABSTRACT

Background: The purpose of this study is to evaluate serum creatinine as a marker of estimated glomerular filtration rate (eGFR) in excessive alcohol use people, and to determine correlation between total kidney volume (TKV) and other relevant factors.  
Methods: In this study, 95 people were examined 2025. We measured serum creatinine based GFR using the MDRD formula. Biochemical analysis and serum creatinine were evaluated using a fully automatic analyzer. TKV was determined by ellipsoid method using 2D sonographic transducer.
Result: The mean subject age was 52±10, BMI 25±4 and male female ratio was 4:1. Mean arterial pressure was 108±14 mmHg, eGFR 90±19 ml/min/1.73m2.  Age, body mass index (BMI) and mean arterial pressure (MAP) were inversely correlated with eGFR (P<0.01) and no difference between male and female recipients. There is no statistically significant correlation between TKV and eGFR. BMI and arterial pressure was correlated with TKV (P<0.01). Mean eGFR and TKV was calculated into 4 groups of 10-year intervals, that eGFR was decreased significantly with age groups.  
Conclusion: According to our research, one of the optimal methods for assessing kidney function is the creatinine-based calculation method, and long-term excessive alcohol consumption is a risk factor for chronic kidney disease (CKD).

KEYWORDS

Glomerular Filtration Rate Kidney Volume Alcohol Dependence

CITATION (Vancouver)

Nayanbuu E, Dorjpalam G, Sainjargal Z, Altan N, Aviisuren K. A Study of Glomerular Filtration and Kidney Volume in Patients with Alcohol Dependence. Central Asian Journal of Nephrology. 2026;2(1):cajn011. https://doi.org/10.63946/cajn/18271
APA
Nayanbuu, E., Dorjpalam, G., Sainjargal, Z., Altan, N., & Aviisuren, K. (2026). A Study of Glomerular Filtration and Kidney Volume in Patients with Alcohol Dependence. Central Asian Journal of Nephrology, 2(1), cajn011. https://doi.org/10.63946/cajn/18271
Harvard
Nayanbuu, E., Dorjpalam, G., Sainjargal, Z., Altan, N., and Aviisuren, K. (2026). A Study of Glomerular Filtration and Kidney Volume in Patients with Alcohol Dependence. Central Asian Journal of Nephrology, 2(1), cajn011. https://doi.org/10.63946/cajn/18271
AMA
Nayanbuu E, Dorjpalam G, Sainjargal Z, Altan N, Aviisuren K. A Study of Glomerular Filtration and Kidney Volume in Patients with Alcohol Dependence. Central Asian Journal of Nephrology. 2026;2(1), cajn011. https://doi.org/10.63946/cajn/18271
Chicago
Nayanbuu, Erdenebat, Ganbat Dorjpalam, Zoljargal Sainjargal, Nyamsuren Altan, and Khorolgarav Aviisuren. "A Study of Glomerular Filtration and Kidney Volume in Patients with Alcohol Dependence". Central Asian Journal of Nephrology 2026 2 no. 1 (2026): cajn011. https://doi.org/10.63946/cajn/18271
MLA
Nayanbuu, Erdenebat et al. "A Study of Glomerular Filtration and Kidney Volume in Patients with Alcohol Dependence". Central Asian Journal of Nephrology, vol. 2, no. 1, 2026, cajn011. https://doi.org/10.63946/cajn/18271

REFERENCES

  1. World Health Organization. Alcohol. Available from: https://www.who.int/news-room/fact-sheets/detail/alcohol
  2. Shao L, Chen Y, Zhao Z, Luo S. Association between alcohol consumption and all-cause mortality, cardiovascular disease, and chronic kidney disease. Medicine. 2024;40(2). https://doi.org/10.1097/MD.000000000003xxxx
  3. Насанжаргал Л, Даваалхам Д, Чимэдсүрэн Б, нар. Зонхилон тохиолдлох сэтгэцийн эмгэгийн тархалт. 2019.
  4. Wakasugi M, Kazama JJ, Yamamoto S, et al. A combination of healthy lifestyle factors is associated with a decreased incidence of chronic kidney disease: a population-based cohort study. Hypertens Res. 2013;36:328–333. https://doi.org/10.1038/hr.2012.186
  5. Dharnidharka VR, Kwon C, Stevens G. Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis. Am J Kidney Dis. 2002;40(2):221–226. https://doi.org/10.1053/ajkd.2002.34487
  6. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Ann Intern Med. 1999;130(6):461–470. https://doi.org/10.7326/0003-4819-130-6-199903160-00002
  7. Насанд хүрэгсдийн артерийн гипертензийн удирдамж. Эрүүл мэндийн яам; 2011.
  8. Janse RJ, Hoekstra T, Jager KJ, Zoccali C, Tripepi G, Dekker FW, van Diepen M. Conducting correlation analysis: important limitations and pitfalls. Clin Kidney J. 2021;14(11):2332–2337. https://doi.org/10.1093/ckj/sfab085
  9. Chen TK, Knicely DH, Grams ME. Chronic kidney disease diagnosis and management: a review. JAMA. 2019;322(13):1294–1304. https://doi.org/10.1001/jama.2019.14745
  10. Wu J, Wang Y, Vlasschaert C, Lali R. Prognostic utility of total kidney volume for chronic kidney disease risk prediction: an observational and Mendelian randomization study. [Journal unknown]. DOI not available.
  11. Perneger TV, Whelton PK, Puddey IB, Klag MJ. Risk of end-stage renal disease associated with alcohol consumption. Am J Epidemiol. 1999;150(12):1275–1281. https://doi.org/10.1093/oxfordjournals.aje.a009958
  12. Koning SH, Gansevoort RT, Mukamal KJ, Rimm EB, Bakker SJ, Joosten MM. Alcohol consumption is inversely associated with the risk of developing chronic kidney disease. Kidney Int. 2015;87:1009–1016. https://doi.org/10.1038/ki.2014.414
  13. Schaeffner ES, Kurth T, de Jong PE, et al. Alcohol consumption and the risk of renal dysfunction in apparently healthy men. Arch Intern Med. 2005;165:1048–1053. https://doi.org/10.1001/archinte.165.9.1048
  14. Yamagata K, Ishida K, Sairenchi T, et al. Risk factors for chronic kidney disease in a community-based population: a 10-year follow-up study. Kidney Int. 2007;71:159–166. https://doi.org/10.1038/sj.ki.5002017
  15. Shield KD, Parry C, Rehm J. Chronic diseases and conditions related to alcohol use. Alcohol Res. 2013;35:155–173.
  16. Weinstein JR, Anderson S. The aging kidney: physiological changes. Adv Chronic Kidney Dis. 2010;17(4):302–307. https://doi.org/10.1053/j.ackd.2010.05.002

LICENSE

Creative Commons License
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.