CENTRAL ASIAN JOURNAL OF NEPHROLOGY
Original Article
Oct 13, 2026 4 2

Relationship Between CD44 and Glomerular Filtration Rate in Chronic Kidney Disease

Yerke Suleimenova 1 2,
Saltanat Moldakhmetova 2,
Abuali Kuspanov 2,
Ainur Abdrakhmanova 2,
Zikrillo Artikov 3,
Abduzhappar Gaipov 2 4 *
1 Department of Clinical Pharmacology, Astana Medical University, Astana, Kazakhstan2 Department of Medicine, School of Medicine, Nazarbayev University, Astana, Kazakhstan3 Department, National Medical Science Center, Astana, Kazakhstan4 Clinical Academic Department of Internal Medicine, University Medical Center, Astana, Kazakhstan* Corresponding Author
Central Asian Journal of Nephrology, 2(3), 2026, cajn018, https://doi.org/10.63946/cajn/19613
Publication date: Oct 13, 2026
Full Text (PDF)

ABSTRACT

Background: Chronic kidney disease (CKD) is very important to have biomarker that can be detected in time before kidney function is impaired, because it is only detected at very late stages. CD44 is a potential biomarker for kidney injury, involved in inflammation and fibrosis.
Methods: This cross-sectional study included 137 participants: The concentration of CD44 urine was measured by enzyme-linked immunosorbent assay (ELISA), and proteomic analysis was performed by mass spectrometry. For assessment, estimated glomerular filtration rate (eGFR) and 24-hour proteinuria have been monitored, while accounting for clinical and laboratory parameters. The correlation between kidney function and CD44 levels was determined using Spearman’s rank correlation.
Results: The level of CD44 in urine, as detected by ELISA, was higher in healthy controls than in CKD patients (p = 0.007). In addition, a positive correlation was observed between CD44 levels and eGFR (Spearman’s rho = 0.2808, p = 0.0052), indicating that higher CD44 levels are associated with kidney function. Proteomic analysis confirmed these results, showing a significant relationship between CD44 expression and kidney function parameters.
Conclusion: The research results demonstrate that CD44 levels in urine differ significantly between healthy individuals and CKD patients, suggesting that CD44 may be a candidate biomarker associated with kidney function. Further investigation in large-scale studies is required to confirm its clinical applicability.

KEYWORDS

Chronic Kidney Disease (CKD) CD44 Egfr Proteinuria Albuminuria ELISA

CITATION (Vancouver)

Suleimenova Y, Moldakhmetova S, Kuspanov A, Abdrakhmanova A, Artikov Z, Gaipov A. Relationship Between CD44 and Glomerular Filtration Rate in Chronic Kidney Disease. Central Asian Journal of Nephrology. 2026;2(3):cajn018. https://doi.org/10.63946/cajn/19613
APA
Suleimenova, Y., Moldakhmetova, S., Kuspanov, A., Abdrakhmanova, A., Artikov, Z., & Gaipov, A. (2026). Relationship Between CD44 and Glomerular Filtration Rate in Chronic Kidney Disease. Central Asian Journal of Nephrology, 2(3), cajn018. https://doi.org/10.63946/cajn/19613
Harvard
Suleimenova, Y., Moldakhmetova, S., Kuspanov, A., Abdrakhmanova, A., Artikov, Z., and Gaipov, A. (2026). Relationship Between CD44 and Glomerular Filtration Rate in Chronic Kidney Disease. Central Asian Journal of Nephrology, 2(3), cajn018. https://doi.org/10.63946/cajn/19613
AMA
Suleimenova Y, Moldakhmetova S, Kuspanov A, Abdrakhmanova A, Artikov Z, Gaipov A. Relationship Between CD44 and Glomerular Filtration Rate in Chronic Kidney Disease. Central Asian Journal of Nephrology. 2026;2(3), cajn018. https://doi.org/10.63946/cajn/19613
Chicago
Suleimenova, Yerke, Saltanat Moldakhmetova, Abuali Kuspanov, Ainur Abdrakhmanova, Zikrillo Artikov, and Abduzhappar Gaipov. "Relationship Between CD44 and Glomerular Filtration Rate in Chronic Kidney Disease". Central Asian Journal of Nephrology 2026 2 no. 3 (2026): cajn018. https://doi.org/10.63946/cajn/19613
MLA
Suleimenova, Yerke et al. "Relationship Between CD44 and Glomerular Filtration Rate in Chronic Kidney Disease". Central Asian Journal of Nephrology, vol. 2, no. 3, 2026, cajn018. https://doi.org/10.63946/cajn/19613

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