Volume 1, Issue 2, 2025
(Ongoing)
Case Report
Central Asian Journal of Nephrology, 1(2), 2025, cajn006, https://doi.org/10.63946/cajn/16982
ABSTRACT:
A 41-year old female patient who underwent kidney transplantation as an outcome of chronic glomerulonephritis came to the hospital with the signs of acute upper respiratory tract infection. As the patient further developed oliguria, peripheral edema, fever, and an increased BP, she was further relocated to the University Medical Center (UMC). Upon admission to UMC, signs of septic shock were detected, and acute transplant rejection was suspected, to exclude which kidney biopsy was performed and stage 3 chronic kidney disease (CKD) in allograft kidney was detected. Antibacterial treatment as well as pulse therapy were performed as patient had septic shock and tubulointerstitial nephritis (TIN).
Original Article
Central Asian Journal of Nephrology, 1(2), 2025, cajn007
ABSTRACT:
Background: Chronic kidney disease (CKD) is a major global health challenge, yet population-based data from Central Asia are scarce. We conducted a population-based screening study to assess kidney function distribution and associated risk factors in Astana, Kazakhstan.
Methods: In March 2024, 636 adults were screened through convenience sampling at four major institutions in Astana. After excluding incomplete data, 569 participants were analyzed. Demographic, lifestyle, and clinical information were collected, and serum creatinine was used to estimate glomerular filtration rate (eGFR). Reduced renal function was defined as eGFR <90 mL/min/1.73 m². Group comparisons and logistic regression analyses were performed to identify risk factors for reduced renal function.
Results: The median age of participants was 46 years (IQR 33–55), and 79.8% were women. Median eGFR was 92.8 (IQR 79.8–111.3) mL/min/1.73 m²; 54.1% had eGFR ≥90, 42.4% had eGFR 60–89, and 3.5% had eGFR 45–59. Reduced renal function was more common among older adults, females and those with hypertension and heart failure. In multivariable analysis, older age and female sex were independent predictors of reduced renal function. Awareness was low: only 15.0% of individuals with eGFR 45–59 reported having CKD.
Conclusion: This study provides the population-based evidence on kidney function in Astana, Kazakhstan. Reduced renal function was common, particularly among older adults. Findings highlight the importance of population-based screening and targeted prevention strategies to address kidney health in Kazakhstan.
Methods: In March 2024, 636 adults were screened through convenience sampling at four major institutions in Astana. After excluding incomplete data, 569 participants were analyzed. Demographic, lifestyle, and clinical information were collected, and serum creatinine was used to estimate glomerular filtration rate (eGFR). Reduced renal function was defined as eGFR <90 mL/min/1.73 m². Group comparisons and logistic regression analyses were performed to identify risk factors for reduced renal function.
Results: The median age of participants was 46 years (IQR 33–55), and 79.8% were women. Median eGFR was 92.8 (IQR 79.8–111.3) mL/min/1.73 m²; 54.1% had eGFR ≥90, 42.4% had eGFR 60–89, and 3.5% had eGFR 45–59. Reduced renal function was more common among older adults, females and those with hypertension and heart failure. In multivariable analysis, older age and female sex were independent predictors of reduced renal function. Awareness was low: only 15.0% of individuals with eGFR 45–59 reported having CKD.
Conclusion: This study provides the population-based evidence on kidney function in Astana, Kazakhstan. Reduced renal function was common, particularly among older adults. Findings highlight the importance of population-based screening and targeted prevention strategies to address kidney health in Kazakhstan.